Google lit up the hornet's nest yesterday when they announced that they were dropping built-in support of H.264 for their own 'open' WebM and OGG video formats.
I reconfigured Xmarks on all my computers (to sync all my bookmarks between FireFox, Safari and Chrome), and I'm back to using Safari full-time, with FireFox as my main backup. (FF 4.0 can't come soon enough).
It was good knowing ye, Chrome. I actually had my sights set on using Chrome indefinitely until yesterday.