Drupal is a scalable, flexible, and open source content management system that is built to run on a variety of server architectures. The only real requirement is that PHP runs on your system. You can run Linux, Microsoft, Mac OS X, etc., along with Apache, IIS, nginx, MariaDB, MySQL, PostgreSQL, etc. if you're willing to do a few extra things.
However, the overwhelming majority of Drupal websites use the most popular LAMP stack on the backend: Linux, Apache, MySQL and PHP, or the 'LEMP' variation, with Nginx instead of Apache. This white paper (which is a living document – I'll be updating it as time progresses) provides my thoughts on performance considerations for Drupal on a LAMP stack, but this information can be used for pretty much any system on any server, if you look at the basic principles.